BMS-986195

Igoa vaila'au:

(S) -4-(3-(ae-2-ynamido) piperidin-1-yl) -5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide

SMILES Code:

FC1=C(N2CCC[C@H](NC(C#CC)=O)C2)C3=C(NC(C)=C3C)C(C(N)=O)=C1

InChi Code:

InChI=1S/C20H23FN4O2/c1-4-6-16(26)24-13-7-5-8-25(10-13)19-15(21)9-14(20(22)27)18 -17(19)11(2)12(3)23-18/h9,13,23H,5,7-8,10H2,1-3H3,(H2,22,27)(H,24,26)/ t13-/m0/s1

InChi Key:

VJPPLCNBDLZIFG-ZDUSSCGKSA-N

upu autu:

BMS-986195, BMS 986195, BMS986195, 1912445-55-6

Solubility:Solu i le DMSO

Teuina:0 - 4°C mo taimi pupuu (aso i vaiaso), poo le -20°C mo taimi uumi (masina).

Fa'amatalaga:

BMS-986195 o se malosi, covalent, le mafai ona toe fa'afo'isia inhibitor o Bruton's tyrosine kinase (BTK), o se sui o le aiga Tec o non-receptor tyrosine kinases taua i antigen-faalagolago B-cell faailoilo ma galuega. BMS-986195 e sili atu nai lo le 5000-filifili filifilia mo BTK i luga o kinases uma i fafo atu o le aiga Tec, ma le filifilia e amata mai le 9- i le 1010-filifili i totonu o le aiga Tec. BMS-986195 inactivated BTK i le toto atoa o le tagata ma se saoasaoa vave o le inactivation (3.5 × 10-4 nM-1 · min-1) ma potently taofia antigen-faalagolago interleukin-6 gaosiga, faʻamatalaga CD86 ma le faʻateleina i sela B (IC50).<1 nM) e aunoa ma se aoga i luga ole antigen-tutoatasi fua i totonu o sela tutusa.

Sini: BTK