BMS-955176

BMS-955176
  • Igoa:BMS-955176
  • Numera fa'amaumauga:CPD3218
  • Numera CAS:1392312-45-6 (fa'avae fua) 2097784-79-5 (TFA)
  • Molecular Weight:690.44
  • Fua Fa'atatau ole vaila'au:C42H62N2O4S
  • Mo na'o su'esu'ega fa'asaienisi, ae le mo gasegase.

    Fa'amatalaga Oloa

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    Igoa vaila'au:

    4-((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-((2-(1,1-dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a -pentamethyl-1-(prop-1-en-2-yl) -2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a ,13b-octadecahydro-1H-cyclopenta[a]chrysen-9-yl)benzoic acid

    SMILES Code:

    O=C(O)C1=CC=C(C2=CC[C@@]3(C)[C@@](C2(C)C)([H])CC[C@@]4(C )[C@]5(C)CC[C@](CC[C@H]6C(C)=C)(NCCN(CC7)CCS7(=O)=O)[C@@]6([H ])[C@@]5([H])CC[C@]34[H])C=C1

    InChi Code:

    InChI=1S/C42H62N2O4S/c1-28(2)31-14-19-42(43-22-23-44-24-26-49(47,48)27-25-44)21-20-40( 6)33(36(31)42)12-13-35-39(5)17-15-32(29-8-10-30(11-9-29)37(45)46)38(3, 4)34(39)16-18-41(35,40)7/h8-11,15,31,33-36,43H,1,12-14,16-27H2,2-7H3,(H,45 ,46)/t31-,33+,34-,35+,36+,39-,40+,41+,42-/m0/s1

    InChi Key:

    XDMUFNNPLXHNKA-ZTESCHFWSA-N

    upu autu:

    GSK3532795, GSK-3532795, GSK 3532795, BMS-955176, BMS 955176, BMS955176

    Solubility: 

    Teuina: 

    Fa'amatalaga:

    GSK3532795, fa'aigoaina fo'i o le BMS-955176, ose malosi, tautala tautala, fa'atupu lona lua HIV-1 fa'amatu'u fa'alavelave (MI) lea na aga'i atu i le vaega IIb fa'ata'ita'iga falema'i. GSK3532795 tu'ufa'atasia lautele fa'asalalauga o fa'ama'i polymorphic (EC50<15 nM agai atu i se vaega o polymorphisms masani sui o le 96.5% HIV-1 subtype B virus) faʻatasi ai ma se faʻataʻitaʻiga lelei pharmacokinetic i ituaiga preclinical.

    Sini: HIV-1 fa'agata matua (MI)


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