BI-2852

Igoa vaila'au:

(S)-5-hydroxy-3-(2-(((1-((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methyl)amino)methyl) -1H-indol-3-yl)isoindolin-1-tasi

SMILES Code:

OC(C=C1)=CC([C@@H](C2=C(CNCC3=CC4=C(C=CN4CC5=CN(C)C=N5)C=C3)NC6=CC=CC=C62) N7)=C1C7=O

InChi Code:

InChI=1S/C31H28N6O2/c1-36-16-21(33-18-36)17-37-11-10-20-7-6-19(12-28(20)37)14-32-15- 27-29(24-4-2-3-5-26(2 4)34-27)30-25-13-22(38)8-9-23(25)31(39)35-30/h2-13,16,18,30,32,34,38H,14- 15,17H2,1H3,(H,35,39)/t30-/m0/s1

InChi Key:

JYEQLXOWWLNVDX-PMERELPUSA-N

upu autu:

Solubility: 

Teuina: 

Fa'amatalaga:

O le BI-2852 o se fa'alavelave KRAS malosi lea e fusifusia i le nanomolar affinity i se taga, e o'o mai i le taimi nei ua manatu e "le mafai ona fa'aogaina," i le va o le ki I ma le II i le RAS. O le BI-2852 e matua'i ma'ese'ese mai fa'ama'i fa'ato'aga KRAG12C aua e fusifusia i se taga 'ese'ese o lo'o i ai i le fa'agaioiga ma le le toaga o KRAS. BI-2852 poloka GEF, GAP, ma fegalegaleaiga faʻapitoa ma KRAS, e taʻitaʻia ai le faʻalavelaveina o faʻailoga i lalo ma se aʻafiaga antiproliferative i sela mutant KRAS.

Sini: KRAS