BAY-850

Igoa vaila'au:

N-((R)-1-(((1s,4S)-4-aminocyclohexyl)amino)-3-(4-cyanophenyl)propan-2-yl)-2-chloro-4-methoxy-5-(5 -((((R)-1-(p-tolyl)ethyl)amino)methyl)furan-2-yl)benzamide

SMILES Code:

ClC(C(C(N[C@H](CC1=CC=C(C#N)C=C1)CN[C@@H]2CC[C@H](N)CC2)=O)=C3 )=CC(OC)=C3C(O4)=CC=C4CN[C@H](C)C5=CC=C(C)C=C5

InChi Code:

InChI=1S/C38H44ClN5O3/c1-24-4-10-28(11-5-24)25(2)42-23-32-16-17-36(47-32)34-19-33(35(35) 39)20-37(34)46-3)38(45)44-31(18-26-6-8-27(21-40)9-7-26)22-43-30-14-12- 29(41)13-15-30/h4-11,16-17,19-20,25,29-31,42-43H,12-15,18,22-23,41H2,1-3H3,(H ,44,45)/t25-,29-,30+,31-/m1/s1

InChi Key:

BSISGUIVBKDTQO-QIKYYPRYSA-N

upu autu:

BAY-850; BAY850; BAY 850

Solubility:DMSO

Teuina: 

Fa'amatalaga:

"BAY-850 o se suʻesuʻega vailaʻau mo le ATAD2A bromodomain lea e sui ai le acetylated H4 peptide mai le ATAD2 bromodomain ma le IC50 tau o le 20 nM (HTRF). 850 faʻaalia le filifilia lelei i luga o isi bromodomains uma (leai ni lavea i BROMOscan i le 10 μM) ma faʻasolo atoa le ATAD2 mai le chromatin i sela ola i le faʻatonuga o le 1 μM e pei ona fuafuaina e le FRAP Ina ia aloese mai faʻalavelave faʻapitoa e le faʻamoemoeina o ≥ 5 µM e le fautuaina (http://www.thesgc.org/chemical-probes/BAY-850) "

Sini: su'esu'ega vaila'au mo le ATAD2A bromodomain