AZD-3409

Igoa vaila'au:

(S)-isopropyl 2-(2-(4-fluorophenethyl)-5-(((2S,4S)-4-(nicotinoylthio)pyrrolidin-2-yl)methyl)amino)benzamido)-4-(methylthio) butanoate

SMILES Code:

O=C(OC(C)C)[C@@H](NC(C1=CC(NC[C@H]2NC[C@@H](SC(C3=CN=CC=C3)=O) C2)=CC=C1CCC4=CC=C(F)C=C4)=O)CCSC

InChi Code:

InChI=1S/C34H41FN4O4S2/c1-22(2)43-33(41)31(14-16-44-3)39-32(40)30-18-27(13-10-24(30)9- 6-23-7-11-26(35)12-8-23)37-20-28-17-29(21-38-28)45-34(42)25-5-4-15-36- 19-25/h4-5,7-8,10-13,15,18-19,22,28-29,31,37-38H,6,9,14,16-17,20-21H2,1- 3H3,(H,39,40)/t28-,29-,31-/m0/s1

InChi Key:

HKGUHEGKBLYKHY-QMOZSOIISA-N

upu autu:

AZD3409; AZD-3409; AZD 3409

Solubility: 

Teuina: 

Fa'amatalaga:

O le AZD-3409 o se faʻamalosi malosi prenyl transferase inhibitor. O le AZD-3409 na faʻaalia le malosi maualuga atu nai lo lonafarnib. O le uiga ole IC(50) mo le cytotoxicity o le AZD3409 e 510 i sela MEF, 10,600 i sela A549 ma 6,170 i sela MCF7, faasologa. I totonu o nei sela, o le IC(50) mo gaoioiga FTase o le AZD3409 e mai le 3.0 i le 14.2 nM ma le lonafarnib mai le 0.26 i le 31.3 nM. O le AZD3409 e taofia ai le mamao i se tulaga maualuga atu nai lo le geranylgeranylation. O fa'alavelave uma o le mamao ma le geranylgeranylation e le mafai ona fa'amaopoopoina i le antiproliferative gaioiga o le vaila'au. AZD3409 atonu o loʻo galue i le gefitinib-resistant carcinoma o le susu.

Manulauti: prenyl transferase inhibitor