STING agonist-3

Izina ryimiti:

(E) -1- (4- (5-carbamoyl-2- en-1-yl) -2- (1-ethyl-3-methyl-1H-pyrazole-5-carboxamido) -7- (3-hydroxypropoxy) -1H-benzo [d] imidazole-5-carboxamide

Kode ya SMILES:

O = C (N) C1 = CC = C (N (C (NC (C2 = CC (C) = NN2CC) = O) = N3) C / C = C / CN4C5 = C (N = C4NC (C6 = CC) (C) = NN6CC) = O) C = C (C (N) = O) C = C5OCCCO) C3 = C1

InChi Code:

InChI = 1S / C37H42N12O6 / c1-5-48-28 (16-21 (3) 44-48) 34 (53) 42-36-40-25-18-23 (32 (38) 51) 10-11- 27 (25) 46 (36) 12-7-8-13-47-31-26 (19-24 (33 (39) 52) 20-30 (31) 55-15-9-14-50) 41- 37 (47) 43-35 (54) 29-17-22 (4) 45-49 (29) 6-2 / h7-8,10-11,16-20,50H, 5-6,9,12- 15H2,1-4H3, (H2,38,51) (H2,39,52) (H, 40,42,53) (H, 41,43,54) / b8-7 +

InChi Urufunguzo:

VHCDRDBBENBVEK-BQYQJAHWSA-N

Ijambo ryibanze:

Gukemura: 

Ububiko: 

Ibisobanuro:

STING agonist-3, yakuwe muri patenti WO2017175147A1 (urugero 10), ni ihitamo kandi itari nucleotide nto-molekile ntoya ya STING agonist hamwe na pEC50 na pIC50 ya 7.5 na 9.5. STING agonist-3 ifite ingaruka zirambye zo kurwanya ibibyimba kandi ifite imbaraga nyinshi zo kunoza imiti ya kanseri

Intego: STING