SB-204990

Izina ryimiti:

trans-5- [6- (2,4-Dichlorophenyl) hexyl] tetrahydro-3-hydroxy-2-oxo-3-aside furanacetic

Kode ya SMILES:

O = C (O) C [C @@] 1 (O) C (O [C @ H] (CCCCCCC2 = CC = C (Cl) C = C2Cl) C1) = O

InChi Code:

InChI = 1S / C18H22Cl2O5 / c19-13-8-7-12 (15 (20) 9-13) 5-3-1-2-4-6-14-10-18 (24,11-16 (21) 22) 17 (23) 25-14 / h7-9,14,24H, 1-6,10-11H2, (H, 21,22) / t14-, 18- / m1 / s1

InChi Urufunguzo:

YTRNLFYTHYWDAU-RDTXWAMCSA-N

Ijambo ryibanze:

SB-204990, SB 204990, SB204990

Gukemura: 

Ububiko: 

Ibisobanuro:

SB-204990 ni prodrug ya ATP citrate-lyase inhibitor SB-201076. SB-204990, iyo yatanzwe mu kanwa ku mbeba, yinjiye mu kuzenguruka kwa sisitemu, ubushakashatsi bwa farumasi bwa SB-201076 bwagaruwe mu mwijima. SB-204990 (25 mg / kg kumunsi) yanagabanije urugero rwa cholesterol ya plasma (kugeza kuri 23%) hamwe na triglyceride (kugeza kuri 38%) mu mbwa, cyane cyane igabanya lipoproteine ​​nkeya cyane ugereranije na cholesterol ya lipoprotein nyinshi. urwego. SB-204990 ni enzyme yingenzi mugucunga itangwa rya substrate ya lipid synthesis de novo hamwe nintego ya enzyme ishobora guterwa na hypolipidaemic.

Intego: