| CPD3611 | SB-204990 | SB-204990 ni prodrug ya ATP citrate-lyase inhibitor SB-201076. SB-204990, iyo yatanzwe mu kanwa ku mbeba, yinjiye mu kuzenguruka kwa sisitemu, ubushakashatsi bwa farumasi bwa SB-201076 bwagaruwe mu mwijima. SB-204990 (25 mg / kg kumunsi) yanagabanije urugero rwa cholesterol ya plasma (kugeza kuri 23%) hamwe na triglyceride (kugeza kuri 38%) mu mbwa, cyane cyane igabanya lipoproteine nkeya cyane ugereranije na cholesterol ya lipoprotein nyinshi. urwego. SB-204990 ni enzyme yingenzi mugucunga itangwa rya substrate ya lipid synthesis de novo hamwe nintego ya enzyme ishobora guterwa na hypolipidaemic. |
