E-7046

Izina ryimiti:

(S) -4- (1- (3- (difluoromethyl) -1-methyl-5- (fenoxy ya 3-

Kode ya SMILES:

O = C (O) C1 = CC = C ([C @@ H] (NC (C2 = C (OC3 = CC = CC (C (F) (F) F) = C3) N (C) N = C2C (F) F) = O) C) C = C1

InChi Code:

InChI = 1S / C22H18F5N3O4 / c1-11 (12-6-8-13 (9-7-12) 21 (32) 33) 28-19 (31) 16-17 (18 (23) 24) 29-30 ( 2) 20 (16) 34-15-5-3-4-14 (10-15) 22 (25,26) 27 / h3-11,18H, 1-2H3, (H, 28,31) (H, 32,33) / t11- / m0 / s1

InChi Urufunguzo:

MKLKAQMPKHNQPR-NSHDSACASA-N

Ijambo ryibanze:

E-7046, E7046, E 7046, 1369489-71-3

Gukemura:Gukemura muri DMSO

Ububiko:0 - 4 ° C mugihe gito (iminsi kugeza ibyumweru), cyangwa -20 ° C mugihe kirekire (amezi).

Ibisobanuro:

Muburyo bwibibyimba bya CT-26, guhuza E7046 / RT bitera inyamanswa yibuka yibibyimba inyamaswa 9. Muri moderi ya 4T1, guhuza E7046 na RT nabyo bitanga umusaruro mwiza wo gukumira ikibyimba cyiza ugereranije na buri muti wonyine. Ihuriro ritezimbere cyane kubaho muguhagarika metastasis yibihaha nyuma yibibyimba 4T1 [1]. E7046 (150 mg / kg) ibuza imikurire yimiterere yibibyimba byinshi. Guhagarika ibimenyetso bya EP4 biteza imbere kurwanya ibibyimba DC kandi bidindiza imikurire yimbeba. Ubuvuzi bwa E7046 bugabanya imikurire cyangwa no kwanga ibibyimba byashizweho muri vivo muburyo bushingiye kuri selile myeloid na CD8C T. Byongeye kandi, gufatanya na E7046 na E7777, poroteyine ya IL-2-diphtheria toxin fusion proteine ​​ikunda kwica Tregs, ikomatanya ihungabanya imiyoboro ya myeloid na Treg immunosuppressive, bikavamo ibisubizo byiza kandi birambye birwanya ubudahangarwa bw'umubiri wibibyimba byimbeba [2] .

Intego: EP4