BAY598 R-isomer

Izina ryimiti:

(R, E) -N- (1- (N'-cyano-N- (3- 4-yl) -N-ethyl-2-hydroxyacetamide

Kode ya SMILES:

CCN ([C @@ H] 1CN (N = C1C2 = CC (Cl) = C (C = C2) Cl) / C (NC3 = CC = CC (OC (F) F) = C3) = N / C # N) C (CO) = O.

InChi Code:

InChI = 1S / C22H20Cl2F2N6O3 / c1-2-31 (19 (34) 11-33) 18-10-32 (30-20 (18) 13-6-7-16 (23) 17 (24) 8-13) 22 (28-12-27) 29-14-4-3-5-15 (9-14) 35-21 (25) 26 / h3-9,18,21,33H, 2,10-11H2,1H3, (H, 28,29) / t18- / m1 / s1

InChi Urufunguzo:

OTTJIRVZJJGFTK-GOSISDBHSA-N

Ijambo ryibanze:

BAY-598 R-isomer; BAY 598 R-isomer; BAY598 R-isomer

Gukemura:DMSO

Ububiko: 

Ibisobanuro:

BAY-598 R-isomer ni R-isomer ya BAY589. BAY-598 R-isomer irashobora gukoreshwa nkibintu bifatika. BAY-598 nubushakashatsi bukomeye, peptide-irwanya imiti ya SMYD2. BAY-598 ifite chemotype idasanzwe ugereranije nubushakashatsi bwa SMYD2 bwa LLY-507. BAY-598 ibuza vitro methylation ya p53K370 hamwe na IC50 = 27 nM kandi ifite inshuro zirenga 100 guhitamo izindi methyltransferase ya histone hamwe nizindi ntego zitari epigenetike. BAY-598 ibuza methylation ya p53K370 muri selile hamwe na IC50<1 µM. . BAY-369 ibuza vitro methylation ya p53K370 hamwe na IC50>Micromolar 70.

Intego: