BAY-850

Izina ryimiti:

N - ((R) -1 - (((1s, 4S) -4-aminocyclohexyl) amino) -3- (4-cyanophenyl) propan-2-yl) -2-chloro-4-mikorerexy-5- (5 - ((((R) -1- (p-tolyl) ethyl) amino) methyl) furan-2-yl) benzamide

Kode ya SMILES:

ClC (C (C (N [C @ H]) (CC1 = CC = C (C # N) C = C1) CN [C @@ H] 2CC [C @ H] (N) CC2) = O) = C3 ) = CC (OC) = C3C (O4) = CC = C4CN [C @ H] (C) C5 = CC = C (C) C = C5

InChi Code:

InChI = 1S / C38H44ClN5O3 / c1-24-4-10-28 (11-5-24) 25 (2) 42-23-32-16-17-36 (47-32) 34-19-33 (35 ( 39) 20-37 (34) 46-3) 38 (45) 44-31 (18-26-6-8-27 (21-4) 0) 9-7-26) 22-43-30-14-12-29 (41) 13-15-30 / h4-11,16-17,19-20,25,29-31,42-43H, 12-15,18,22-23,41H2,1-3H3, (H, 44,45) / t25-, 29-, 30 +, 31- / m1 / s1

InChi Urufunguzo:

BSISGUIVBKDTQO-QIKYYPRYSA-N

Ijambo ryibanze:

BAY-850; BAY850; BAY 850

Gukemura:DMSO

Ububiko: 

Ibisobanuro:

. 850 yerekana guhitamo neza kurenza izindi bromodomain zose (nta hit muri BROMOscan kuri 10 µM) na Kwimura ATAD2 yuzuye kuva muri chromatin muri selile nzima kuri concentration ya 1 µM nkuko byagenwe na FRAP Kugirango wirinde ingaruka zidasobanutse neza ziterwa na ≥ 5 µM ntabwo byemewe (http://www.thesgc.org/chemical -probes / BAY-850) "

Intego: iperereza ryimiti kuri ATAD2A bromodomain