Quarfloxin

Quarfloxin
  • Dzina:Quarfloxin
  • Catalog No.:CPD2205
  • Nambala ya CAS:865311-47-3
  • Kulemera kwa Molecular:604.67
  • Chemical formula:Chithunzi cha C35H33FN6O3
  • Zofufuza zasayansi zokha, osati za odwala.

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    Dzina la Chemical:

    5-fluoro-N-(2-((S)-1-methylpyrrolidin-2-yl)ethyl)-3-oxo-6-((R)-3-(pyrazin-2-yl)pyrrolidin-1-yl )-3H-benzo[b]pyrido[3,2,1-kl]phenoxazine-2-carboxamide

    SMILES Kodi:

    FC1=C(N2CC[C@@H](C3=CN=CC=N3)C2)C(OC4=C5C=C6C(C=CC=C6)=C4)=C(N5C=C(C(NCC[ C@H]7N(C)CCC7)=O)C8=O)C8=C1

    InChi kodi:

    InChI=1S/C35H33FN6O3/c1-40-13-4-7-24(40)8-10-39-35(44)26-20-42 -29-15-21-5-2-3-6-22(21)16-30(29)45-34-31(42)25(33(26)43)17-27 (36)32(34)41-14-9-23(19-41)28-18-37-11-12-38-28/h2-3,5-6,11-12 ,15-18,20,23-24H,4,7-10,13-14,19H2,1H3,(H,39,44)/t23-,24+/m1/s1

    InChi Key:

    WOQIDNWTQOYDLF-RPWUZVMVSA-N

    Mawu ofunika:

    CX 3543; CX-3543; CX 3543; Quarfloxacin

    Kusungunuka: 

    Posungira: 

    Kufotokozera:

    Quarfloxin, yomwe imadziwikanso kuti Quarfloxacin ndi CX-3543, ndi yochokera ku fluoroquinolone yokhala ndi ntchito ya antineoplastic. Quarfloxin imasokoneza mgwirizano pakati pa mapuloteni a nucleolin ndi G-quadruplex DNA mu template ya ribosomal DNA (rDNA), kuyanjana kofunikira kwa rRNA biogenesis yomwe imakhala yowonjezereka m'maselo a khansa; Kusokonezeka kwa G-quadruplex DNA iyi: kuyanjana kwa mapuloteni mu aberrant rRNA biogenesis kungayambitse kuletsa kwa ribosome synthesis ndi chotupa cell apoptosis.

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