prenyl transferase

MPAKA #	Dzina lazogulitsa	Kufotokozera
Chithunzi cha CPD3233	AZD-3409	AZD-3409 ndi inhibitor yamphamvu ya prenyl transferase. AZD-3409 inawonetsa potency yapamwamba kuposa lonafarnib. IC(50) ya cytotoxicity ya AZD3409 inali 510 m'maselo a MEF, 10,600 m'maselo a A549 ndi 6,170 m'maselo a MCF7, motsatira. M'maselo amenewa, IC(50) ya ntchito ya FTase ya AZD3409 inachokera ku 3.0 mpaka 14.2 nM ndi ya lonafarnib kuchokera ku 0.26 mpaka 31.3 nM. AZD3409 imalepheretsa farnesylation kumlingo wapamwamba kuposa geranylgeranylation. Kuletsa kwa farnesylation ndi geranylgeranylation sikungagwirizane ndi ntchito ya antiproliferative ya mankhwala. AZD3409 ikhoza kukhala yogwira ntchito mu carcinoma yolimbana ndi gefitinib.