Etoricoxib

Dzina la Chemical:

5-Chloro-6'-methyl-3--[4-(methylsulfonyl)phenyl] -2,3'-bipyridine

SMILES Kodi:

O=S(C1=CC=C(C2=CC(Cl)=CN=C2C3=CC=C(C)N=C3)C=C1)(C)=O

InChi kodi:

InChI=1S/C18H15ClN2O2S/c1-12-3-4-14(10-20-12)18-17(9-15(19)11-21-18)13-5-7-16(8-6- 13)24(2,22)23/h3-11H,1-2H3

InChi Key:

MNJVRJDLRVPLFE-UHFFFAOYSA-N

Mawu ofunika:

Etoricoxib, Arcoxia, L-791456, MK 0663, MK-0663, 202409-33-4

Kusungunuka:Zosungunuka mu DMSO

Posungira:0 - 4 ° C kwa nthawi yochepa (masiku mpaka masabata), kapena -20 ° C kwa nthawi yaitali (miyezi)

Kufotokozera:

Etoricoxib ndi mankhwala opangira, osagwirizana ndi kutupa (NSAID) omwe ali ndi antipyretic, analgesic, ndi anti-antineoplastic properties. Etoricoxib imamangiriza ndikuletsa enzyme cyclooxygenase-2 (COX-2), zomwe zimapangitsa kuletsa kutembenuka kwa arachidonic acid kukhala prostaglandins. Kuletsa kwa COX-2 kungapangitse apoptosis ndikuletsa kuchulukana kwa maselo a chotupa ndi angiogenesis.

Cholinga: COX-2