BMS-986195
Tsatanetsatane wa Zamalonda
Zogulitsa Tags
| Paketi Kukula | Kupezeka | Mtengo (USD) |
| 100 mg | Zilipo | 300 |
| 500 mg | Zilipo | 850 |
| 1g | Zilipo | 1200 |
| Makulidwe Enanso | Pezani Mawu | Pezani Mawu |
Dzina la Chemical:
(S) -4-(3-(koma-2-ynamido)piperidin-1-yl)-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide
SMILES Kodi:
FC1=C(N2CCC[C@H](NC(C#CC)=O)C2)C3=C(NC(C)=C3C)C(C(N)=O)=C1
InChi kodi:
InChI=1S/C20H23FN4O2/c1-4-6-16(26)24-13-7-5-8-25(10-13)19-15(21)9-14(20(22)27)18 -17(19)11(2)12(3)23-18/h9,13,23H,5,7-8,10H2,1-3H3,(H2,22,27)(H,24,26)/ t13-/m0/s1
InChi Key:
VJPPLCNBDLZIFG-ZDUSSCGKSA-N
Mawu ofunika:
BMS-986195, BMS 986195, BMS986195, 1912445-55-6
Kusungunuka:Zosungunuka mu DMSO
Posungira:0 - 4 ° C kwa nthawi yochepa (masiku mpaka masabata), kapena -20 ° C kwa nthawi yaitali (miyezi).
Kufotokozera:
BMS-986195 ndi choletsa champhamvu, chogwirizana, chosasinthika cha Bruton's tyrosine kinase (BTK), membala wa banja la Tec la non-receptor tyrosine kinases yofunikira pakuzindikiritsa ndi ntchito ya B-cell yodalira antigen. BMS-986195 ndiyosankhira BTK mopitilira 5000 pamakina onse akunja kwa banja la Tec, ndipo kusankha kumayambira 9- mpaka 1010 mkati mwa banja la Tec. BMS-986195 inactivated BTK m'magazi athunthu a anthu ndi kuthamanga kwachangu (3.5 × 10-4 nM-1·min-1) komanso kulepheretsa antigen-dependent interleukin-6 kupanga, CD86 kufotokoza ndi kuchuluka kwa maselo a B (IC50)<1 nM) popanda zotsatira za antigen-zodziyimira pawokha m'maselo omwewo.
Cholinga: BTK
