Mtengo wa BI-2852

Dzina la Chemical:

(S) -5-hydroxy-3-(2-((((1-((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methyl)amino)methyl) -1H-indol-3-yl) isoindolin-1-imodzi

SMILES Kodi:

OC(C=C1)=CC([C@@H](C2=C(CNCC3=CC4=C(C=CN4CC5=CN(C)C=N5)C=C3)NC6=CC=CC=C62) N7)=C1C7=O

InChi kodi:

InChI=1S/C31H28N6O2/c1-36-16-21(33-18-36)17-37-11-10-20-7-6-19(12-28(20)37)14-32-15- 27-29(24-4-2-3-5-26(24)34-27)30-25-13-22(38)8-9-23(25)31(39)35-30/h2- 13,16,18,30,32,34,38H,14-15,17H2,1H3,(H,35,39)/t30-/m0/s1

InChi Key:

JYEQLXOWWLNVDX-PMERELPUSA-N

Mawu ofunika:

Kusungunuka: 

Posungira: 

Kufotokozera:

BI-2852 ndi inhibitor yamphamvu ya KRAS yomwe imamangiriza ndi nanomolar kuyanjana ndi thumba, mpaka pano ikuwoneka ngati "yosasinthika," pakati pa switch I ndi II pa RAS. BI-2852 ndi yosiyana ndi makina a KRASG12C inhibitors chifukwa imamangiriza ku thumba lina lomwe likupezeka mumitundu yogwira komanso yosagwira ntchito ya KRAS. BI-2852 imatchinga GEF, GAP, ndi kuyanjana kwamphamvu ndi KRAS, zomwe zimapangitsa kuletsa kutsika kwa siginecha komanso antiproliferative m'maselo osinthika a KRAS.

Cholinga: KRAS