S-600918,Sivopixant

S-600918,Sivopixant
  • Nomen:S-600918,Sivopixant
  • Catalogue No.CPD109617
  • CAS No.:2414285-40-6
  • Pondus hypotheticum:507.93
  • Formulae chemica:C25 H22 Cl N5 O5
  • Investigationes scientificae tantum, non aegros.

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    Nomen chemicum:

    (2S)-3-[(4E)-3-[(4-chlorophenyl) methyl]-2,6-dioxo-4-({4-[(pyridin-2-yl)oxy]phenyl}imino)-1 ,3,5-triazinan-1-yl]

    SMILES Code:

    O=C(O)[C@@H](C)CN1C(N(CC2=CC=C(Cl)C=C2)/C(NC1=O)=N/C3=CC=C(OC4=NC =CC=C4)C=C3)=O

    InChi Code:

    InChI=1S/C25H22ClN5O5/c1-16(22(32)33)14-31-24(34)29-23(30(25(31)35)15-17-5-7-18(26)8- 6-17)28-19-9-11-20(12-10-19)36-21-4-2-3-13-27-21/h2-13,16H,14-15H2,1H3,(H ,32,33)(H,28,29,34)/t16-/m0/s1

    InChi Key:

    SKZQFKBIJUXXCG-INIZCTEOSA-N

    Keyword:

    2414285-40-6; CAS:2414285-40-6; CAS:2414285-40-6; Sivopixant; S-600918; S 600918; S600918

    Solubilitas:Solutum in DMSO

    Repono:Arida, obscura et ad 0 - 4 C ad terminum brevem (dies ad septimanas) vel -20 C ad terminum longum (menses ad annos);

    Descriptio:

    Sivopixant, quae etiam S-600918 nota est, P2X3 receptator adversarius est selectivus (P2X3 IC50, 4.2 nM; P2X2/3 IC50, 1100 nM). Sivopixant effectum analgesicum validum ostendit in rat nervi ischiadici partialis exemplar ligationis (exemplari Seltzer) allodyniae (ED50, 0.4 mg/kg).

    Scopum: selectivam P2X3 receptor adversario




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