Divarasib, GDC 6036

Nomen chemicum:

1-((S)-4-(7-((R)-6-amino-4-methyl-3-(trifluoromethyl)pyridinum-2-yl)-6-chloro-8-fluoro-2-((( S) -1-methylpyrrolidin-2-yl)methoxy)quinazolin-4-yl) -3-methylpiperazin-1-yl)prop-2-en-1-unum

SMILES Code:

NC1=N[C@]([C@]2=C(C=C3C(N=C(N=C3N4[C@H](CN(CC4)C(C=C)=O)C)OC[ C@H]5N(CCC5)C)=C2F)Cl)=C(C(C)=C1)C(F)(F)F

InChi Code:

InChI=1S/C29H32ClF4N7O2/c1-5-21(42)40-9-10-41(16(3)13-40)27-18-12-19(30)22(26-23(32; 33) 34)15(2)11-20(35)36-26)24(31)25(18)37-28(38-27)43-14-17-7-6-8-39(17) 4/h5,11-12,16-17H,1,6-10,13-14H2,2-4H3,(H2,35,36)

InChi Key:

ZRBPIAWWRPFDPY-UHFFFAOYSA-N

Keyword:

2417987-45-0; CAS:2417987-45-0; CAS 2417987-45-0;

Solubilitas:SolubilityTo determinari

Repono:Arida, obscura et ad 0 - 4 C ad terminum brevem (dies ad septimanas) vel -20 C ad terminum longum (menses ad annos).

Descriptio:

Divarasib (GDC-6036) est inhibitor KRAS G12C cum biovariabilitate et selectivity orali.

Target: KRAS G12C inhibitor