BI-2852

Nomen chemicum:

(S) -5-hydroxy-3-(2-((((1-((1-methyl-1H-imidazol-4-yl) methyl) -1H-indol-6-yl) methyl)amino) methyl) -1H-indol-3-yl)isoindolin-1-one

SMILES Code:

OC(C=C1)=CC([C@@H](C2=C(CNCC3=CC4=C(C=CN4CC5=CN(C)C=N5)C=C3)NC6=CC=CC=C62) N7)=C1C7=O

InChi Code:

InChI=1S/C31H28N6O2/c1-36-16-21(33-18-36)17-37-11-10-20-7-6-19(12-28(20)37)14-32-15- 27-29(24-4-2-3-5-26(24)34-27)30-25-13-22(38)8-9-23(25)31(39)35-30/h2- 13,16,18,30,32,34,38H,14-15,17H2,1H3,(H,35,39)/t30-/m0/s1

InChi Key:

JYEQLXOWWLNVDX-PMERELPUSA-N

Keyword:

Solubilitas: 

Repono: 

Descriptio:

BI-2852 potens est KRAS inhibitor qui affinitate cum sinum nanomolar obstringit, hactenus "unrugable" esse perceptum inter I et II in RAS transibit. BI-2852 a covalentibus KRASG12C inhibitoribus mechanistice distinguitur quia obligat ad alium sinum praesentem in formis tam activae quam inac- KRAS. BI-2852 caudices GEF, GAP et cum KRAS interationes effector, ducentes ad inhibitionem amni significationis et effectum antiproliferativum in cellulis mutant KRAS.

Target: KRAS