ARS-1323-Alkyne

Nomen chemicum:

3-((4-(4-acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-2-yl)amino)-N-methyl-N- (prop-2-yn-1-yl) propanamide

SMILES Code:

O=C(N(C)CC#C)CCNC1=NC(N2CCN(C(C=C)O)CC2)=C3C=C(Cl)C(C4=C(O)C=CC=C4F) =C(F)C3=N1

InChi Code:

InChI=1S/C28H27ClF2N6O3/c1-4-11-35(3)22(40)9-10-32-28-33-26-17(27(34-28)37-14-12-36(13- 15-37)21(39)5-2)16-18(29)23(25(26)31)24-19(30)7-6-8-20(24)38/h1,5-8; 16,38H,2,9-15H2,3H3,(H,32,33,34).

InChi Key:

FCCFZQSNDSLLMI-UHFFFAOYSA-N

Keyword:

2436544-27-1；CAS：2436544-27-1；CAS:2436544-27-1；ARS-1323-Alkyne; ARS1323-Alkyne; ARS 1323-Alkyne; ARS-1323 Alkyne

Solubilitas:Solutum in DMSO

Repono:Arida, obscura et ad 0 - 4 C ad terminum brevem (dies ad septimanas) vel -20 C ad terminum longum (menses ad annos).

Descriptio:

ARS-1323-alkyne, pactionis sinum (S-IIP) inhibitor

Target: switch-II pocket (S-IIP)