ARS-1620

Navê Kîmyayî:

(S)-1-(4-(6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one

Koda SMILES:

C=CC(=O)N1CCN(CC1)C2=C3C=C(C(=C4C(=O)C=CC=C4F)C(=C3NC=N2)F)Cl

Koda InChi:

InChI=1S/C21H17ClF2N4O2/c1-2-16(30)27-6-8-28(9-7-27)21-12-10-13(22)17( 19 (24) 20 (12) 25-11-26-21) 18-14 (23) 4-3-5-15 (18) 29/h2-5,10-11,29H,1,6-9H2

Bişkojka InChi:

QIQWMIZVWVSRAS-UHFFFAOYSA-N

Keyword:

ARS-1620, KRAS G12C, NSCLC, ARS1620, ARS 1620, KRASG12C, 1698055-85-4

Çareserî:Di DMSO de çareser dibe

Embarkirinî:0 - 4 ° C ji bo demek kurt (roj heta hefte), an -20 ° C ji bo demek dirêj (mehan)

Terîf:

ARS-1620 prodermanek e ku ji ARS-853 hatî çêkirin, ku astengkerek hêzdar û bijartî ya S-IIP G12C ye. Tê payîn ku ARS-1620 bibe stratejiyek dermankirinê ji bo p.G12C KRAS kanserên mutant.

Armanc: KRAS (K-Ras G12C)