STING agonis-3

Jeneng Kimia:

(E)-1-(4-(5-carbamoyl-2-(1-etil-3-metil-1H-pirazol-5-karboxamido)-1H-benzo[d]imidazol-1-yl)nanging-2- en-1- yl)-2-(1-etil-3-metil-1H-pirazol-5-karboxamido)-7-(3-hidroksipropoksi)-1H-benzo[d]imidazole-5-karboxamide

Kode SMILES:

O=C(N)C1=CC=C(N(C(NC(C2=CC(C)=NN2CC)=O)=N3)C/C=C/CN4C5=C(N=C4NC(C6=CC (C)=NN6CC)=O)C=C(C(N)=O)C=C5OCCCO)C3=C1

Kode Inchi:

InChI=1S/C37H42N12O6/c1-5-48-28(16-21(3)44-48)34(53)42-36-40-25-18-23(3 2(38)51)10-11-27(25)46(36)12-7-8-13-47-31-26(19-24(33(39)52)20-30(31)55- 15-9-14-50)41-37(47)43-35(54)29-17-22(4)45-49(29)6-2/h7-8,10-11,16-20, 50 H,5-6,9,12-15H2,1-4H3,(H2,38,51)(H2,39,52)(H,40,42,53)(H,41,43,54)/b8 -7+

Kunci InChi:

VHCDRDBBENBVEK-BQYQJAHWSA-N

tembung kunci:

Kelarutan: 

Panyimpenan: 

katrangan:

STING agonist-3, diekstrak saka paten WO2017175147A1 (conto 10), minangka agonis STING molekul cilik sing selektif lan non-nukleotida kanthi pEC50 lan pIC50 saka 7,5 lan 9,5. STING agonist-3 nduweni efek anti-tumor sing tahan lama lan potensial banget kanggo ningkatake perawatan kanker

Sasaran: STING