S-600918, Sivopixant

Jeneng Kimia:

(2S)-3-[(4E)-3-[(4-chlorophenyl)metil]-2,6-dioxo-4-({4-[(pyridin-2-yl)oxy]fenil}imino)-1 ,3,5-triazinan-1-yl]-2-metilpropanoat asam

Kode SMILES:

O=C(O)[C@@H](C)CN1C(N(CC2=CC=C(Cl)C=C2)/C(NC1=O)=N/C3=CC=C(OC4=NC =CC=C4)C=C3)=O

Kode Inchi:

InChI=1S/C25H22ClN5O5/c1-16(22(32)33)14-31-24(34)29-23(30(25(31)35)15-17-5-7-18(26)8- 6-17) 28-1 9-9-11-20(12-10-19)36-21-4-2-3-13-27-21/h2-13,16H,14-15H2,1H3,(H,32,33)( H,28,29,34)/t16-/m0/s1

Kunci InChi:

SKZQFKBIJUXXCG-INIZCTEOSA-N

tembung kunci:

2414285-40-6; CAS: 2414285-40-6; CAS: 2414285-40-6; Sivopixant; S-600918; S 600918; S600918

Kelarutan:Larut ing DMSO

Panyimpenan:Garing, peteng lan ing 0 - 4 C kanggo jangka cendhak (dina nganti minggu) utawa -20 C kanggo jangka panjang (sasi nganti taun)

katrangan:

Sivopixant, uga dikenal minangka S-600918, minangka antagonis reseptor P2X3 selektif (P2X3 IC50, 4,2 nM; P2X2/3 IC50, 1100 nM). Sivopixant nuduhake efek analgesik sing kuat ing model ligasi saraf sciatic parsial tikus (model Seltzer) allodynia (ED50, 0.4 mg / kg).

Target: Antagonis reseptor P2X3 selektif