Quarfloxin

Quarfloxin
  • jeneng:Quarfloxin
  • No. Katalog:CPD2205
  • Nomer CAS:865311-47-3
  • Bobot molekul:604.67
  • Formula kimia:C35H33FN6O3
  • Kanggo riset ilmiah mung, ora kanggo pasien.

    Detail Produk

    Tag produk

    Ukuran Paket kasedhiyan Rega (USD)

    Jeneng Kimia:

    5-fluoro-N-(2-((S)-1-methylpyrrolidin-2-yl)etil)-3-oxo-6-((R)-3-(pirazin-2-yl)pyrrolidin-1-yl )-3H-benzo[b]pirido[3,2,1-kl]fenoksazin-2-karboxamide

    Kode SMILES:

    FC1=C(N2CC[C@@H](C3=CN=CC=N3)C2)C(OC4=C5C=C6C(C=CC=C6)=C4)=C(N5C=C(C(NCC[ C@H]7N(C)CCC7)=O)C8=O)C8=C1

    Kode Inchi:

    InChI=1S/C35H33FN6O3/c1-40-13-4-7-24(40)8-10-39-35(44)26-20-42-29-15-21-5-2-3-6- 22(21)16-30(29)45-34-31(42)25(33(26)43)17-27(36)32(34)41-14-9-23(19-41)28- 18-37-11-12-38-28/h2-3,5-6,11-12,15-18,20,23-24H,4,7-10,13-14,19H2,1H3,(H ,39,44)/t23-,24+/m1/s1

    Kunci InChi:

    WOQIDNWTQOYDLF-RPWUZVMVSA-N

    tembung kunci:

    CX 3543; CX-3543; CX 3543; Quarfloxacin

    Kelarutan: 

    Panyimpenan: 

    katrangan:

    Quarfloxin, uga dikenal minangka Quarfloxacin lan CX-3543, minangka turunan fluoroquinolone kanthi aktivitas antineoplastik. Quarfloxin ngganggu interaksi antara protein nukleolin lan struktur DNA G-quadruplex ing cithakan DNA ribosom (rDNA), interaksi kritis kanggo biogenesis rRNA sing diekspresikake kanthi berlebihan ing sel kanker; gangguan DNA G-quadruplex iki: interaksi protein ing biogenesis rRNA aberrant bisa nyebabake inhibisi sintesis ribosom lan apoptosis sel tumor.

    Target:


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