| KUCING # | Jeneng produk | Katrangan |
| CPD3611 | SB-204990 | SB-204990 minangka prodrug saka inhibitor ATP sitrat-lyase kuat SB-201076. SB-204990, nalika ditrapake sacara lisan kanggo tikus, diserap menyang sirkulasi sistemik, konsentrasi farmakologis sing relevan saka SB-201076 ditemokake ing ati. SB-204990 (25 mg / kg saben dina) uga nyuda tingkat kolesterol plasma (nganti 23%) lan tingkat trigliserida (nganti 38%) ing asu, luwih seneng nyuda lipoprotein kapadhetan rendah dibandhingake karo kolesterol lipoprotein kapadhetan dhuwur. tingkatan. SB-204990 minangka enzim penting kanggo ngontrol pasokan substrat kanggo sintesis lipid de novo lan target enzim potensial kanggo intervensi hipolipidamik. |
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