PCO371

Jeneng Kimia:

1-(3,5-dimetil-4-(2-((4-oxo-2-(4-(trifluoromethoxy)fenil))-1,3,8-triazaspiro[4.5]dec-1-en-8-yl )sulfonil)etil)fenil)-5,5-dimethylimidazolidine-2,4-dione

Kode SMILES:

O=C1NC(C(C)(C)N1C2=CC(C)=C(CCS(=O)(N(CC3)CCC3(N=C(C4=CC=C(OC(F)(F))F )C=C4)N5)C5=O)=O)C(C)=C2)=O

Kode Inchi:

InChI=1S/C29H32F3N5O6S/c1-17-15-20(37-26(40)34-24(38)27(37,3)4)16-18(2)22(17)9-14-44( 41,42)36-12-10-28(11-13-36)25(39)33-23(35-28)19-5-7-21(8-6-19)43-29(30, 31)32/h5-8,15-16H,9-14H2,1-4H3,(H,33,35,39)(H,34,38,40)

Kunci InChi:

LDZJFVOUPUFOHX-UHFFFAOYSA-N

tembung kunci:

PCO371; PCO-371; PCO 371

Kelarutan: 

Panyimpenan: 

katrangan:

PCO371 minangka agonis PTHR1 sing kuat lan selektif kanggo perawatan hipoparatiroidisme. Administrasi lisan PCO371 kanggo tikus osteopenik nyebabake paningkatan sing signifikan ing turnover balung kanthi nambah massa balung sing winates. Ing tikus hypocalcemic, PCO371 mulihake tingkat kalsium serum tanpa nambah kalsium urin, lan kanthi efek sing luwih kuat lan tahan suwe tinimbang injeksi PTH.

Sasaran : PT. 1