ND-630
Detail Produk
Tag produk
| Ukuran Paket | kasedhiyan | Rega (USD) |
| 10 mg | Ing saham | 300 |
| 50 mg | Ing saham | 500 |
| 100 mg | Ing saham | 800 |
| Ukuran liyane | Entuk Kutipan | Entuk Kutipan |
Jeneng Kimia:
(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)etil)-5-metil-6-(oxazol-2-yl) -2,4-dioxo-1,2-dihydrothieno[2,3-d]pirimidin-3(4H)-yl)-2-methylpropanamide
Kode SMILES:
O=C(N)C(C)(C)N(C(N(C[C@@H](C1=CC=CC=C1OC)OC2CCOCC2)C3=C4C(C)=C(C5=NC= CO5)S3)=O)C4=O
Kode Inchi:
InChI=1S/C28H31N3O8S/c1-16-21-24(32)31(28(2,3)26(33)34)27(35)30(25(21)40-22(16)23-29- 11-14-38-23)15-20(39-17-9-12-37-13-10-17)18-7-5-6-8-19(18)36-4/h5-8, 11,14,17,20H,9-10,12-13,15H2,1-4H3,(H,33,34)/t20-/m0/s1
Kunci InChi:
ZZWWXIBKLBMCSS-FQEVSTJZSA-N
tembung kunci:
ND-630, ND630, ND 630, GS-0976, GS0976, GS 0976, NDI-010976, NDI010976, NDI 010976, Firsocostat, 1434635-54-7
Kelarutan:Larut ing DMSO
Panyimpenan:0 - 4°C kanggo jangka cendhak (dina nganti minggu), utawa -20°C kanggo jangka panjang (sasi).
katrangan:
ND-630 nyegah hACC1 (IC50 = 2,1 ± 0,2 nM) lan hACC2 (IC50 = 6,1 ± 0,8 nM). Inhibisi bisa dibatalake lan spesifik banget kanggo ACC. ND-630 nyegah aktivitas ACC kanthi interaksi ing situs phosphopeptide-acceptor lan dimerisasi enzim kanggo nyegah dimerisasi. ND-630 nyegah sintesis asam lemak kanthi EC50 saka 66 nM ing sel HepG2 tanpa ngowahi jumlah sel total, konsentrasi protein seluler, lan penggabungan asetat menyang kolesterol [1].
Sasaran: ACC
