Ertugliflozin

Jeneng Kimia:

(1S,2S,3S,4R,5S)-5-(4-chloro-3-(4-ethoxybenzyl)phenyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3 ,4-triol

Kode SMILES:

"CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)C34C(C(C(C(O3)(CO4)CO)O)O)O)Cl "

Kode Inchi:

"InChI=1S/C22H25ClO7/c1-2-28-16-6-3-13(4-7-16)9-14-10-15(5-8-17(14)23)22-20(27) )18(25)19(2 6)21(11-24,30-22)12-29-22/h3-8,10,18-20,24-27H,2,9,11-12H2,1H3/t18-,19-,20+ ,21-,22-/m0/s1 "

Kunci InChi:

"MCIACXAZCBVDEE-CUUWFGFTSA-N"

tembung kunci:

Ertugliflozin, PF 04971729, MK-8835,1210344-57-2

Kelarutan:Larut ing DMSO

Panyimpenan:0 - 4°C kanggo jangka cendhak (dina nganti minggu), utawa -20°C kanggo jangka panjang (sasi).

katrangan:

Ertugliflozin, uga dikenal minangka PF-04971729, minangka inhibitor kuat lan selektif saka cotransporter glukosa gumantung sodium 2 lan calon klinis kanggo perawatan diabetes mellitus jinis 2. Pasinaon klinis nuduhake yen Ertugliflozin (1-25 mg / dina) nambah kontrol glikemik, bobot awak lan tekanan getih ing pasien T2DM sing dikontrol kanthi metformin kanthi suboptimal, lan ditoleransi kanthi apik.

Sasaran: SGLT-2