BAY598 R-isomer
Detail Produk
Tag produk
| Ukuran Paket | kasedhiyan | Rega (USD) |
| 50 mg | ing saham | Entuk kutipan |
| 250 mg | ing saham | Entuk kutipan |
| 500 mg | ing saham | Entuk kutipan |
Jeneng Kimia:
(R,E)-N-(1-(N'-cyano-N-(3-(difluoromethoxy)fenil)carbamidoyl)-3-(3,4-diklorofenil)-4,5-dihydro-1H-pirazol- 4-yl)-N-etil-2-hydroxyacetamide
Kode SMILES:
CCN([C@@H]1CN(N=C1C2=CC(Cl)=C(C=C2)Cl)/C(NC3=CC=CC(OC(F)F)=C3)=N/C# N)C(CO)=O
Kode Inchi:
InChI=1S/C22H20Cl2F2N6O3/c1-2-31(19(34)11-33)18-10-32(30-20(18)13-6-7-16(23)17(24)8-13) 22 ( 28-12-27)29-14-4-3-5-15(9-14)35-21(25)26/h3-9,18,21,33H,2,10-11H2,1H3,(H ,28,29)/t18-/m1/s1
Kunci InChi:
OTTJIRVZJJGFTK-GOSISDBHSA-N
tembung kunci:
BAY-598 R-isomer; BAY 598 R-isomer; BAY598 R-isomer
Kelarutan:DMSO
Panyimpenan:
katrangan:
BAY-598 R-isomer yaiku R-isomer saka BAY589. BAY-598 R-isomer bisa digunakake minangka senyawa referensi. BAY-598 minangka probe kimia kompetitif peptida sing kuat kanggo SMYD2. BAY-598 nduweni chemotype unik relatif kanggo probe kimia SMYD2 saiki LLY-507. BAY-598 nyegah metilasi in vitro p53K370 kanthi IC50 = 27 nM lan nduweni selektivitas luwih saka 100 kali lipat liwat metiltransferase histon liyane lan target non-epigenetik liyane. BAY-598 nyegah metilasi p53K370 ing sel kanthi IC50< 1 µM. (Saliyane iki, BAY-598 nduweni sifat sing kompatibel karo eksperimen in vivo.) Senyawa kontrol, BAY-369, uga wis dikembangake. BAY-369 nyegah metilasi in vitro p53K370 kanthi IC50>70 mikromolar.
Target:
