AZD7507

Jeneng Kimia:

4-(2-fluoro-4-methylanilino)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-7-methoxycinnoline-3-carboxamide

Kode SMILES:

O=C(C1=NN=C2C=C(OC)C(N3CCN(CCO)CC3)=CC2=C1NC4=CC=C(C)C=C4F)N

Kode Inchi:

InChI=1S/C23H27FN6O3/c1-14-3-4-17(16(24)11-14)26-21-15-12-19(30-7-5-29(6-8-30)9- 10-31)20(33-2)13-18(15)27-28-22(21)23(25)32/h3-4,11-13,31H,5-10H2,1-2H3,(H2 ,25,32)(H,26,27)

Kunci InChi:

CPDGCAFPSYOTGO-UHFFFAOYSA-N

tembung kunci:

AZD7507; AZD-7507; AZD 7507

Kelarutan:DMSO

Panyimpenan: 

katrangan:

AZD7507 minangka inhibitor CSF-1R sing kuat lan selektif (aktivitas sel 32 nM), AZD7507 dianggep minangka senyawa sing njanjeni amarga njaga potensi sing dikarepake lan sifat farmakokinetik lisan AZ683. Kajaba iku, ing studi telemetri ing asu sing diwenehi dosis oral siji, ora ana keracunan kardiovaskular, ora ana elevasi troponin sing ana hubungane karo perawatan, lan ora ana owah-owahan ing ECG.

Sasaran: CSF-1R