SB-204990

Aha kemịkalụ:

trans-5-[6- (2,4-Dichlorophenyl) hexyl] tetrahydro-3-hydroxy-2-oxo-3-furanacetic acid

Koodu Ọchịchọ:

O=C(O)C[C@@]1(O)C(O[C@H](CCCCCCCC2=CC=C(Cl)C=C2Cl)C1)=O

Koodu InChi:

InChi=1S/C18H22Cl2O5/c19-13-8-7-12(15(20)9-13)5-3-1-2-4-6-14-10-18(24,11-16(21) 22)17 (23)25-14/h7-9,14,24H,1-6,10-11H2,(H,21,22)/t14-,18-/m1/s1

Igodo InChi:

YTRNLFYTHYWDAU-RDTXWAMCSA-N

Okwu:

SB-204990, SB 204990, SB204990

Solubility: 

Nchekwa: 

Nkọwa:

SB-204990 bụ prodrug nke ike ATP citrate-lyase inhibitor SB-201076. SB-204990, mgbe a na-enye oke ọnụ ọnụ, etinyere ya na mgbasa ozi sistemu, a na-enwetakwa mkpokọta ọgwụ SB-201076 n'ime imeju. SB-204990 (25 mg / kg kwa ụbọchị) na-ebelata ọkwa cholesterol plasma (ruo 23%) na ọkwa triglyceride (ruo 38%) na nkịta, ọkacha mma na-ebelata lipoprotein dị ala ma e jiri ya tụnyere cholesterol lipoprotein dị elu. ọkwa. SB-204990 bụ enzyme dị mkpa n'ịchịkwa mkpụrụ maka njikọ lipid de novo yana ebumnuche enzyme nwere ike ime maka ntinye aka hypolipidemia.

Ebumnuche: