| CPD3611 | SB-204990 | SB-204990 bụ prodrug nke ike ATP citrate-lyase inhibitor SB-201076. SB-204990, mgbe a na-enye oke ọnụ ọnụ, etinyere ya na mgbasa ozi sistemu, a na-enwetakwa mkpokọta ọgwụ SB-201076 n'ime imeju. SB-204990 (25 mg / kg kwa ụbọchị) na-ebelata ọkwa cholesterol plasma (ruo 23%) na ọkwa triglyceride (ruo 38%) na nkịta, ọkacha mma na-ebelata lipoprotein dị ala ma e jiri ya tụnyere cholesterol lipoprotein dị elu. ọkwa. SB-204990 bụ enzyme dị mkpa n'ịchịkwa mkpụrụ maka njikọ lipid de novo yana ebumnuche enzyme nwere ike ime maka ntinye aka hypolipidemia. |
