nwamba # | Aha ngwaahịa | Nkọwa |
CPD3218 | BMS-955176 | GSK3532795, nke a makwaara dị ka BMS-955176, bụ onye nwere ike, na-arụsi ọrụ ike ọnụ, ọgbọ nke abụọ HIV-1 maturation inhibitor (MI) nke gara n'ihu site na ule ụlọ ọgwụ IIb. GSK3532795 na-ejikọta nnukwu mkpuchi nke nje polymorphic (EC50<15 nM n'ebe otu panel nke polymorphisms nkịtị nke nje 96.5% HIV-1 subtype B) nwere profaịlụ pharmacokinetic dị mma na ụdị preclinical. |