BMS-955176

BMS-955176
  • Aha:BMS-955176
  • Nọmba katalọgụ:CPD3218
  • Nọmba CAS:1392312-45-6 (ụkpụrụ efu) 2097784-79-5 (TFA)
  • Arọ Molecular:690.44
  • Usoro kemịkalụ:C42H62N2O4S
  • Maka nyocha sayensị naanị, ọ bụghị maka ndị ọrịa.

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    Aha kemịkalụ:

    4-(1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-(2- (1,1-dioxidothiomorpholino)ethyl)amino) -5a,5b,8,8,11a -pentamethyl-1- (prop-1-en-2-yl) -2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a ,13b-octadecahydro-1H-cyclopenta[a] chrysen-9-yl) benzoic acid

    Koodu Ọchịchọ:

    O=C(O)C1=CC=C(C2=CC[C@@]3(C)[C@@](C2(C)C)([H])CC[C@@]4(C) )[C@]5(C)CC[C@](CC[C@H]6C(C)=C)(NCCN(CC7)CCS7(=O)=O)[C@@]6([H) ])[C@@]5([H])CC[C@]34[H])C=C1

    Koodu InChi:

    InChi=1S/C42H62N2O4S/c1-28(2)31-14-19-42(43-22-23-44-24-26-49(47,48)27-25-44)21-20-40( 6)33 (36 (31)42)12-13-35-39 (5)17-15-32 (29-8-10-30 (11-9-29)37 (45)46)38 (3, 4)34(39)16-18-41(35,40)7/h8-11,15,31,33-36,43H,1,12-14,16-27H2,2-7H3,(H,45 ,46)/t31-,33+,34-,35+,36+,39-,40+,41+,42-/m0/s1

    Igodo InChi:

    XDMUFNNPLXHNKA-ZTESCHFWSA-N

    Okwu:

    GSK3532795, GSK-3532795, GSK 3532795, BMS-955176, BMS 955176, BMS955176

    Solubility: 

    Nchekwa: 

    Nkọwa:

    GSK3532795, nke a makwaara dị ka BMS-955176, bụ onye nwere ike, na-arụsi ọrụ ike ọnụ, ọgbọ nke abụọ HIV-1 maturation inhibitor (MI) nke gara n'ihu site na ule ụlọ ọgwụ IIb. GSK3532795 na-ejikọta nnukwu mkpuchi nke nje polymorphic (EC50<15 nM n'ebe otu panel nke polymorphisms nkịtị nke nje 96.5% HIV-1 subtype B) nwere profaịlụ pharmacokinetic dị mma na ụdị preclinical.

    Ebumnuche: HIV-1 maturation inhibitor (MI)


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