IACS-010759

Aha kemịkalụ:

5- (5-methyl-1- (3- (4- (methylsulfonyl)) piperidin-1-yl) benzyl) -1H-1,2,4-triazol-3-yl) -3- (4- (trifluoromethoxy) phenyl -1,2,4-oxadiazole

Koodu Ọchịchọ:

FC(F)(F) OC1=CC=C(C2=NOC(C3=NN(CC4=CC=CC(N5CCC(S(=O)(C)=O)CC5)=C4)C(C)= N3)=N2)C=C1

Koodu InChi:

InChi=1S/C25H25F3N6O4S/c1-16-29-23(24-30-22(32-38-24)18-6-8-20(9-7-18)37-25(26,27)28) 31 -34 (16) 15-17-4-3-5-19 (14-17) 33-12-10-21 (11-13-33) 39 (2,35) 36/h3-9,14,21H ,10-13,15H2,1-2H3

Igodo InChi:

HWJWNWZJUYCGKV-UHFFFAOYSA-N

Okwu:

IACS-010759, IACS 010759, IACS010759, IACS-10759, IACS 10759, IACS10759, 1570496-34-2, 1807523-99-4

Solubility:Soluble na DMSO

Nchekwa:0 - 4 Celsius C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 Celsius maka ogologo oge (ọnwa).

Nkọwa:

IACS-010759 ma ọ bụ IACS-10759 bụ onye nwere ike na nhọrọ Oxidative Phosphorylation Inhibitor (IC50)<10 nM) nwere ike ịrụ ọrụ antineoplastic. IACS-010759 na-ejikọ ma na-egbochi mgbagwoju I nke eriri ụgbọ njem elektrọn (NADH ubiquinone oxidoreductase), si otú ahụ na-ewepụ mkpụrụ ndụ tumor nke nri, na ume, na igbochi mmepụta nucleotide na amino acid, nke na-ebute autophagy, na-akpata ọnwụ cell tumor ma na-egbochi cell cell. mmụba. Mitochondrial complex I, bụ nke a na-arụ ọrụ na mkpụrụ ndụ kansa iji gboo mkpa ha na-achọ ike, na-ekere òkè dị mkpa n'ịkwalite mmụba nke cell cancer.

Ebumnuche: OXPHOS