E-7046

Aha kemịkalụ:

(S) -4- (1- (3- (difluoromethyl) -1-methyl-5- (3- (trifluoromethyl) phenoxy) -1H-pyrazole-4-carboxamido) ethyl) benzoic acid.

Koodu Ọchịchọ:

O=C(O)C1=CC=C([C@@H](NC(C2=C(OC3=CC=CC(C(F)(F)F)=C3)N(C)N=C2C (F)F=O)C)C=C1

Koodu InChi:

InChi=1S/C22H18F5N3O4/c1-11(12-6-8-13(9-7-12)21(32)33)28-19(31)16-17(18(23)24)29-30( 2 )20(16)34-15-5-3-4-14(10-15)22(25,26)27/h3-11,18H,1-2H3,(H,28,31)(H,32 ,33)/t11-/m0/s1

Igodo InChi:

MKLKAQMPKHNQPR-NSHDSACASA-N

Okwu:

E-7046, E7046, E 7046, 1369489-71-3

Solubility:Soluble na DMSO

Nchekwa:0 - 4 Celsius C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 Celsius maka ogologo oge (ọnwa).

Nkọwa:

Na ụdị tumor CT-26, nchikota E7046/RT na-akpata nzaghachi ebe nchekwa ihe mgbochi nke anụmanụ 9. Na ụdị 4T1, nchikota nke E7046 na RT na-arụpụtakwa ọrụ mgbochi uto tumor dị mma ma e jiri ya tụnyere ọgwụgwọ ọ bụla naanị. Ngwakọta a na-eme ka ndụ dịkwuo mma site na igbochi metastasis akpa ume na-esote nke etuto 4T1[1]. E7046 (150 mg/kg) na-egbochi uto nke ọtụtụ ụdị tumor syngeneic. Mgbochi nke akara ngosi EP4 na-akwalite mgbochi tumor DC iche ma na-ebelata uto tumor na ụmụ oke. Ọgwụgwọ E7046 na-ebelata uto ma ọ bụ ọbụna jụ etuto siri ike na vivo n'ụzọ dabere na sel myeloid na CD8C T. Ọzọkwa, ngalaba nchịkwa nke E7046 na E7777, protein IL-2-diphtheria toxin fusion nke na-egbu Tregs, synergistically na-akpaghasị myeloid na Treg immunosuppressive netwọk, na-ebute nzaghachi mgbochi tumor dị irè na nke na-adịgide adịgide na ụdị tumor tumor[2] .

Ebumnuche: EP4