ND-630
Pwodwi detay
Tags pwodwi
| Gwosè pake | Disponibilite | Pri (USD) |
| 10 mg | Nan stock | 300 |
| 50 mg | Nan stock | 500 |
| 100 mg | Nan stock | 800 |
| Plis gwosè | Jwenn Quotes | Jwenn Quotes |
Non Chimik:
(R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl) -2,4-dioxo-1,2-dihydrothieno[2,3-d]pirimidin-3(4H)-yl)-2-methylpropanamide
Kòd SMILES:
O=C(N)C(C)(C)N(C(N(C[C@@H](C1=CC=CC=C1OC)OC2CCOCC2)C3=C4C(C)=C(C5=NC= CO5)S3)=O)C4=O
Kòd InChi:
InChI=1S/C28H31N3O8S/c1-16-21-24(32)31(28(2,3)26(33)34)27(35)30(25(21)40-22(16)23-29- 11-14-38-23)15-20(39-17-9-12-37-13-10-17)18-7-5-6-8-19(18)36-4/h5-8, 11,14,17,20H,9-10,12-13,15H2,1-4H3,(H,33,34)/t20-/m0/s1
InChi kle:
ZZWWXIBKLBMCS-FQEVSTJZSA-N
Mot:
ND-630, ND630, ND 630, GS-0976, GS0976, GS 0976, NDI-010976, NDI010976, NDI 010976, Firsocostat, 1434635-54-7
Solibilite:Soluble nan DMSO
Depo:0 - 4 ° C pou kout tèm (jou a semèn), oswa -20 ° C pou tèm long (mwa).
Deskripsyon:
ND-630 inibit hACC1 (IC50 = 2.1±0.2 nM) ak hACC2 (IC50 = 6.1±0.8 nM). Anpèchman se revèsib ak trè espesifik pou ACC. ND-630 inibit aktivite ACC lè li kominike nan sit fosfopeptid akseptè a ak dimerizasyon anzim lan pou anpeche dimerizasyon. ND-630 inibit sentèz asid gra ak yon EC50 nan 66 nM nan selil HepG2 san yo pa chanje kantite selil total, konsantrasyon pwoteyin selilè, ak enkòporasyon acetate nan kolestewòl [1].
Sib: ACC
