Etorikoksib

Non Chimik:

5-Chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-2,3'-bipiridin

Kòd SMILES:

O=S(C1=CC=C(C2=CC(Cl)=CN=C2C3=CC=C(C)N=C3)C=C1)(C)=O

Kòd InChi:

InChI=1S/C18H15ClN2O2S/c1-12-3-4-14(10-20-12)18-17(9-15(19)11-21-18)13-5-7-16(8-6- 13)24(2,22)23/h3-11H,1-2H3

InChi kle:

MNJVRJDLRVPLFE-UHFFFAOYSA-N

Mot:

Etorikoksib, Arcoxia, L-791456, MK 0663, MK-0663, 202409-33-4

Solibilite:Soluble nan DMSO

Depo:0 - 4 ° C pou kout tèm (jou a semèn), oswa -20 ° C pou tèm long (mwa)

Deskripsyon:

Etoricoxib se yon sentetik, nonsteroidal anti-enflamatwa dwòg (NSAID) ak antipiretik, analgesic, ak potansyèl pwopriyete antineoplastic. Etoricoxib espesyalman mare ak inibit anzim cyclooxygenase-2 (COX-2), sa ki lakòz anpèchman konvèsyon asid arachidonik nan prostaglandin. Anpèchman COX-2 ka pwovoke apoptoz ak anpeche pwopagasyon selil timè ak anjojenèz.

Sib: COX-2