BMS-986165

Non chimik:

6-(cyclopropanecarboxamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)piridazin-3 -karboksamid

Kòd SMILES:

O=C(C1=NN=C(NC(C2CC2)=O)C=C1NC3=CC=CC(C4=NN(C)C=N4)=C3OC)NC([2H])([2H])[ 2H]

Kòd InChi:

InChI=1S/C20H22N8O3/c1-21-20(30)16-14(9-15(25-26-16)24-19(29)11-7-8-11)23-13-6-4- 5-12 (17(13)31-3)18-22-10-28(2)27-18/h4-6,9-11H,7-8H2,1-3H3,(H,21,30)(H2,23 ,24,25,29)/i1D3

InChi kle:

BZZKEPGENYLQSC-FIBGUPNXSA-N

Mot:

1609392-27-9；CAS:1609392-27-9；CAS:1609392-27-9；BMS-986165; BMS 986165; BMS986165; Deucravacitinib

Solibilite:Soluble nan DMSO

Depo:Sèk, nwa ak nan 0 - 4 C pou kout tèm (jou a semèn) oswa -20 C pou tèm long (mwa a ane).

Deskripsyon:

BMS-986165 se yon inibitè allosterik trè pwisan ak selektif nan TYK2. BMS-986165 Bloke Il-12, IL-23 ak siyal entèferon tip I epi li bay yon efikasite solid nan modèl preklinik maladi enflamatwa entesten. MS-986165 mare nan domèn pseudokinase Tyk2 (Ki = 0.02 nM), epi li trè selektif kont yon panèl 265 kinaz ak pseudokinases. Konpoze a pisan anpeche IL-23-, IL-12-, ak Tip I entèferon-kondwi siyal selilè ak repons transcriptional (IC50 ranje 2-14 nM).

Sib: TYK2