BAY-598

BAY-598
  • Non:BAY-598
  • Nimewo katalòg:CPD1616
  • Nimewo CAS:1906919-67-2 (S-izomè) 1906920-28-2 (BAY598 R-izomè) 1906920-07-7 (BAY598 melanj rekamik)
  • Pwa molekilè:524.09
  • Fòmil chimik:C22H20Cl2F2N6O3
  • Pou rechèch syantifik sèlman, pa pou pasyan yo.

    Pwodwi detay

    Tags pwodwi

    Gwosè pake Disponibilite Pri (USD)

    Non chimik:

    (S,E)-N-(1-(N'-cyano-N-(3-(difluoromethoxy)phenyl)carbamimidoyl)-3-(3,4-diklorophenyl)-4,5-dihydro-1H-pirazol- 4-yl)-N-etil-2-hydroxyacetamide

    Kòd SMILES:

    CCN(C(CO)=O)[C@H]1CN(/C(NC2=CC=CC(OC(F)F)=C2)=N/C#N)N=C1C3=CC(Cl)= C(Cl)C=C3

    Kòd InChi:

    InChI=1S/C22H20Cl2F2N6O3/c1-2-31(19(34)11-33)18-10-32(30-20(18)13-6-7-16(23)17(24)8-13) 22(28-12-27)29-14-4-3-5-15(9-14)35-21(25)26/h3-9,18,21,33H,2,10-11H2,1H3, (H,28,29)/t18-/m0/s1

    InChi kle:

    OTTJIRVZJJGFTK-SFHVURJKSA-N

    Mot:

    BAY-598; BAY 598; BAY598

    Solibilite:DMSO

    Depo: 

    Deskripsyon:

    BAY-598 se yon pwofonde chimik ki pisan, peptide-konpetitif pou SMYD2. BAY-598 gen yon chemotype inik parapò ak aktyèl pwofonde chimik SMYD2 LLY-507 la. BAY-598 inibit in vitro methylation nan p53K370 ak IC50 = 27 nM epi li gen plis pase 100-pliye selektivite sou lòt methyltransferases histon ak lòt sib ki pa epigenetik. BAY-598 inibit metilasyon p53K370 nan selil ki gen IC50.< 1 µM. (Anplis de sa, BAY-598 gen pwopriyete ki konpatib ak eksperyans nan vivo.) Yo te devlope yon konpoze kontwòl, BAY-369 tou. BAY-369 inibit metilasyon an vitro nan p53K370 ak IC50>70 mikromolar.

    Sib: pwofonde chimik pou SMYD2


  • Previous:
  • Pwochen:

  • Pwodwi ki gen rapò

    Chat sou entènèt WhatsApp!