AZD-3409

Non Chimik:

(S)-isopropyl 2-(2-(4-fluorophenethyl)-5-((((2S,4S)-4-(nicotinoylthio)pyrrolidin-2-yl)methyl)amino)benzamido)-4-(methylthio) butanoate

Kòd SMILES:

O=C(OC(C)C)[C@@H](NC(C1=CC(NC[C@H]2NC[C@@H])(SC(C3=CN=CC=C3)=O) C2)=CC=C1CCC4=CC=C(F)C=C4)=O)CCSC

Kòd InChi:

InChI=1S/C34H41FN4O4S2/c1-22(2)43-33(41)31(14-16-44-3)39-32(40)30 -18-27(13-10-24(30)9-6-23-7-11-26(35)12-8-23)37-20-28-17-29(21-38) -28)45-34(42)25-5-4-15-36-19-25/h4-5,7-8,10-13,15,18-19,22,28-29, 31,37-38H,6,9,14,16-17,20-21H2,1-3H3,(H,39,40)/t28-,29-,31-/m0/s1

InChi kle:

HKGUHEGKBLYKHY-QMOZSOIISA-N

Mot:

AZD3409; AZD-3409; AZD 3409

Solibilite: 

Depo: 

Deskripsyon:

AZD-3409 se yon inibitè prenyl transferase ki pisan. AZD-3409 te montre pi gwo puisans pase lonafarnib. Mwayèn IC(50) pou cytotoxicity nan AZD3409 te 510 nan selil MEF, 10,600 nan selil A549 ak 6,170 nan selil MCF7, respektivman. Nan selil sa yo, IC(50) pou aktivite FTase nan AZD3409 varye ant 3.0 a 14.2 nM ak nan lonafarnib soti nan 0.26 a 31.3 nM. AZD3409 inibit farnesylation nan yon limit ki pi wo pase geranylgeranylation. Tou de anpèchman farnesylation ak geranylgeranylation pa t 'kapab gen rapò ak aktivite a antiproliferative nan dwòg la. AZD3409 ta ka aktif nan kansè nan tete ki reziste gefitinib.

Sib: inibitè prenyl transferase