PEB-667

Lub npe tshuaj:

(1s,4R)-N-((S)-1-(4-(4-fluoro-1H-pyrazol-1-yl)phenyl)ethyl)-1-methoxy-4-(4-methyl-6-( (5-methyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)cyclohexane-1-carboxamide

SMILES Code:

CC1=NC([C@@H]2CC[C@](C(N[C@@H](C)C3=CC=C(N4N=CC(F)=C4)C=C3)=O) (OC)CC2)=NC(NC5=NNC(C)=C5)=C1

InChi Code:

InChI=1S/C28H33FN8O2/c1-17-13-24(33-25-14-18(2)35-36-25)34-26(31-17)21-9-11-28(39-4, 12-10-21) 27(38)32-19(3)20-5-7-23(8-6-20)37-16-22(29)15-30-37/h5-8,13- 16,19,21H,9-12H2,1-4H3,(H,32,38)(H2,31,33,34,35,36)/t19-,21-,28+/m0/s1

InChi Key:

HUQPYQIGHTXBNW-BDHWGLMFSA-N

Lo lus tseem ceeb:

BLU-667; BLU 667; PAB 667

Solubility:DMSO

Cia: 

Nqe lus piav qhia:

BLU-667 yog ib qho muaj zog thiab xaiv inhibitor ntawm RET kev hloov pauv, fusions, thiab kwv yees tiv thaiv mutants. RET fusions yog cov tsav tsheb tseem ceeb ntawm ntau yam mob qog noj ntshav, suav nrog mob ntsws thiab mob qog noj ntshav, thiab peb cov kev tshawb fawb qhia tias RET tseem ua lub luag haujlwm tseem ceeb hauv qee qhov mob qog noj ntshav thiab lub mis. Los ntawm tib lub hom phiaj rau tus thawj tsav tsheb thiab kwv yees cov mutants resistant uas ua rau cov qog nqaij hlav cancer insensitive rau kev kho mob nrog cov tshuaj pom zoo tam sim no,

Hom phiaj: RET