PEB-299

Lub npe tshuaj:

2-(2,3-dihydro-1,3,6-trimethyl-2-oxo-1H-benzimidazol-5-yl)-6-(3-hydroxypropyl)-1H-benz[de]isoquinoline-1,3( 2H) - ib

SMILES Code:

OCCCC1=CC=C(C(N2C3=C)C(C)C=C(N(C)C(N4C)=O)C4=C3)=O)C5=C1C=CC=C5C2=O

InChi Code:

InChI = 1S/C25H23N3O4/c1-14-12-20-21(27(3)25(32)26(20)2)13-19(14)28-23(30)17-8- 4-7-16-15(6-5-11-29)9-10-18(22(16)17)24(28)31/h4,7-10,12-13,29H,5-6, 11 H2, 1-3H3

InChi Key:

OFWWWWKWUCDUISA-UHFFFAOYSA-N

Lo lus tseem ceeb:

UA-299, BAY 299, BAY299, 2080306-23-4

Solubility:Soluble hauv DMSO

Cia:0 - 4 ° C rau lub sijhawm luv (hnub mus rau lub lis piam), lossis -20 ° C rau lub sijhawm ntev (hli).

Nqe lus piav qhia:

BAY-299 yog ib qho muaj zog thiab xaiv inhibitor ntawm bromodomain thiab PHD ntiv tes uas muaj (BRPF) tsev neeg cov protein BRD1 (IC50 = 6 nM), tseem hu ua BRPF2, thiab qhov thib ob bromodomain ntawm kev pib pib qhov tseem ceeb TFIID subunits 1 (TAF1; IC50 = 13 nM).1 BAY-299 yog>30-fold xaiv dua BRPF1, BRPF3, BRD9, thiab ATAD2 thiab yog> 300-fold xaiv tshaj BRD4.

Hom phiaj: BRPF