PEB-293

Lub npe tshuaj:

(R)-6,7-dimethoxy-2-methyl-N-(1-(4-(2-((methylamino)methyl)phenyl)thiophen-2-yl)ethyl)quinazolin-4-amine

SMILES Code:

C[C@@H](NC1=C2C=C(OC)C(OC)=CC2=NC(C)=N1)C3=CC(C4=CC=CC=C4CNC)=CS3

InChi Code:

InChI = 1S/C25H28N4O2S/c1-15(24-10-18(14-32-24)19-9-7-6-8-17(19)13-26-3)27-25-20-11- 22( 30-4) 23(31-5)12-21(20)28-16(2)29-25/h6-12,14-15,26H,13H2,1-5H3,(H,27,28,29) ) /t15-/m1/s1

InChi Key:

WEGLOYDTDILXDA-OAHLOKOSA-N

Lo lus tseem ceeb:

BAY-293, UA 293, BAY293

Solubility: 

Cia: 

Nqe lus piav qhia:

BAY-293 yog ib qho muaj zog SOS1 inhibitor uas thaiv RAS ua kom muaj kev cuam tshuam ntawm RAS-SOS1 kev cuam tshuam. BAY-293) xaiv inhibits KRAS-SOS1 kev cuam tshuam nrog IC50 ntawm 21 nM thiab yog ib qho tseem ceeb tshuaj soj ntsuam rau kev tshawb nrhiav yav tom ntej.

Hom phiaj: SOS1 inhibitor