Ozanimod

Lub npe tshuaj:

(S)-5-(3-(1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-yl)-1,2,4-oxadiazol-5-yl)-2 - isopropoxybenzonitrile

SMILES Code:

N#CC1=CC(C2=NC(C3=CC=CC4=C3CC[C@@H]4NCCO)=NO2)=CC=C1OC(C)C

InChi Code:

InChI = 1S/C23H24N4O3/c1-14(2)29-21-9-6-15(12-16(21)13-24)23-26-22(27-30-23)19-5-3- 4-18-17(19)7-8-20(18)25-10-11-28/h3-6,9,12,14,20,25,28H,7-8,10-11H2,1- 2H3/t20-/m0/s1

InChi Key:

XRVDGNKRPOAQTN-FQEVSTJZSA-N

Lo lus tseem ceeb:

Ozanimod, RPC-1063, RPC1063, RPC 1063, 1306760-87-1

Solubility:Soluble hauv DMSO

Cia:0 - 4 ° C rau lub sijhawm luv (hnub mus rau lub lis piam), lossis -20 ° C rau lub sijhawm ntev (hli).

Nqe lus piav qhia:

Ozanimod yog ib qho kev xaiv, hais lus muaj modulator ntawm sphingosine-1-phosphate (S1P) receptors S1P1 thiab SIP5. Nws induces internalization ntawm S1P1, txo circulating B thiab CCR7 (+) T lymphocytes, thiab txo o thiab kab mob tsis nyob rau hauv peb autoimmune kab mob qauv.1 Ozanimod yog nyob rau hauv kev sim tshuaj rau relapsing ntau yam sclerosis thiab ulcerative colitis.

Hom phiaj: S1P