ARS-1620

Lub npe tshuaj:

(S)-1-(4-(6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-ib

SMILES Code:

C=CC(=O)N1CCN(CC1)C2=C3C=C(C(=C4C(=O)C=CC=C4F)C(=C3NC=N2)F)Cl

InChi Code:

InChI=1S/C21H17ClF2N4O2/c1-2-16(30)27-6-8-28(9-7-27)21-12-10-13(22)17( 19(24)20(12)25-11-26-21)18-14(23)4-3-5-15(18)29/h2-5,10-11,29H,1,6-9H2

InChi Key:

QIQWMIZVWVSRAS-UHFFFAOYSA-N

Lo lus tseem ceeb:

ARS-1620, KRAS G12C, NSCLC, ARS1620, ARS 1620, KRASG12C, 1698055-85-4

Solubility:Soluble hauv DMSO

Cia:0 - 4 ° C rau lub sijhawm luv (hnub mus rau lub lis piam), lossis -20 ° C rau lub sijhawm ntev (hli)

Nqe lus piav qhia:

ARS-1620 yog ib tug prodrug tsim los ntawm ARS-853, uas yog ib tug muaj zog thiab xaiv S-IIP G12C inhibitor. ARS-1620 yuav tsum yog lub tswv yim kho mob rau p.G12C KRAS mutant qog noj ntshav.

Hom phiaj: KRAS (K-Ras G12C)