TH-302; Evofosfamide

Lub npe tshuaj:

N, N'-Bis (2-bromoethyl) phosphorodiamidic acid (1-methyl-2-nitro-1H-imidazol-5-yl)methyl ester

SMILES Code:

O=P(NCCBr)(NCCBr)OCC1=CN=C([N+]([O-])=O)N1C

InChi Code:

InChI=1S/C9H16Br2N5O4P/c1-15-8(6-12-9(15)16(17)18)7-20-21(19,13-4-2-10)14-5-3-11/ h6H,2-5,7H2,1H3,(H2,13,14,19)

InChi Key:

UGJWRPJDTDGERK-UHFFFAOYSA-N

Lo lus tseem ceeb:

TH-302, TH302, TH 302, Evofosfamide, 918633-87-1

Solubility:Soluble hauv DMSO

Cia:0 - 4 ° C rau lub sijhawm luv (hnub mus rau lub lis piam), lossis -20 ° C rau lub sijhawm ntev (hli)

Nqe lus piav qhia:

Evofosfamide, tseem hu ua TH-302, yog hypoxia-activated prodrug uas muaj 2-nitroimidazole phosphoramidate conjugate nrog muaj peev xwm ua haujlwm antineoplastic. 2-nitroimidazole moiety ntawm hypoxia-activated prodrug TH-302 ua raws li ib tug hypoxic trigger, tso DNA-alkylating dibromo isophosphoramide mustard moiety nyob rau hauv hypoxic cheeb tsam ntawm cov qog. Cov ntaub so ntswg Normoxic tuaj yeem raug cawm dim vim yog qhov ua haujlwm ntawm hypoxia tshwj xeeb ntawm tus neeg sawv cev no, uas tuaj yeem txo cov kab mob toxicity. Tshawb xyuas cov kev sim tshuaj kho mob lossis kaw qhov kev sim tshuaj uas siv tus neeg sawv cev no. (NCI).

Hom phiaj: DNA Alkylating Agent