BAZ2-ICR

Lub npe tshuaj:

4-(4-(1-methyl-1H-pyrazol-4-yl)-1-(2-(1-methyl-1H-pyrazol-4-yl)ethyl)-1H-imidazol-5-yl)benzonitrile

SMILES Code:

CN(N=C1)C=C1C2=C(C3=CC=C(C#N)C=C3)N(CCC4=CN(C)N=C4)C=N2

InChi Code:

InChI=1S/C20H19N7/c1-25-12-16(10-23-25)7-8-27-14-22-19(18-11-24) -26(2)13-18-20(27)17-5-3-15(9-21)4-6-17/h3-6,10-14H,7-8H2,1-2H3

InChi Key:

RRZVGDGTWNQAPW-UHFFFAOYSA-N

Lo lus tseem ceeb:

BAZ2-ICR, BAZ2ICR, BAZ2 ICR, 1665195-94-7

Solubility:Soluble hauv DMSO

Cia:0 - 4 ° C rau lub sijhawm luv (hnub mus rau lub lis piam), lossis -20 ° C rau lub sijhawm ntev (hli).

Nqe lus piav qhia:

BAZ2-ICR yog ib qho tshuaj zoo heev rau kev tshawb fawb txog kev ua haujlwm ntawm BAZ2 bromodomains hauv vitro thiab hauv vivo. Lub bromodomain uas muaj cov proteins BAZ2A / B ua lub luag haujlwm tseem ceeb hauv kev hloov kho chromatin thiab kev tswj hwm ntawm noncoding RNAs. BAZ2-ICR muaj IC50 (BAZ2A) = 130 nM; IC50(BAZ2B) = 180 nM; logD = 1.05; solubility 25 mM (D2O) thiab F = 70%.

Hom phiaj: BAZ2