STING agonist-3
Huahana Huahana
Huahana Huahana
Nui Puke | Loaʻa | Kumukuai (USD) |
Inoa Kimia:
(E)-1-(4-(5-carbamoyl-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-1H-benzo[d]imidazol-1-yl)akā-2- en-1- yl)-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-(3-hydroxypropoxy)-1H-benzo[d]imidazole-5-carboxamide
SMILES Code:
O=C(N)C1=CC=C(N(C(NC(C2=CC(C)=NN2CC)=O)=N3)C/C=C/CN4C5=C(N=C4NC(C6=CC) (C)=NN6CC)=O)C=C(C(N)=O)C=C5OCCCO)C3=C1
Code InChi:
InChI=1S/C37H42N12O6/c1-5-48-28(16-21(3)44-48)34(53)42-36-40-25-18-23(3 2(38)51)10-11-27(25)46(36)12-7-8-13-47-31-26(19-24(33(39)52)20-30(31)55- 15-9-14-50)41-37(47)43-35(54)29-17-22(4)45-49(29)6-2/h7-8,10-11,16-20, 50 H,5-6,9,12-15H2,1-4H3,(H2,38,51)(H2,39,52)(H,40,42,53)(H,41,43,54)/b8 -7+
Ki InChi:
VHCDRDBBENBVEK-BQYQJAHWSA-N
Hua'ōlelo:
Hiki ke hoʻoheheʻe:
Waihona:
wehewehe:
ʻO STING agonist-3, i unuhi ʻia mai ka patent WO2017175147A1 (laʻana 10), he mea koho a me ka non-nucleotide liʻiliʻi STING agonist me ka pEC50 a me ka pIC50 o 7.5 a me 9.5. Loaʻa i ka STING agonist-3 ka hopena anti-tumor lōʻihi a hiki ke hoʻomaikaʻi i ka mālama ʻana i ka maʻi kanesa
Pahuhopu: STING