SB-204990

Inoa Kimia:

trans-5-[6-(2,4-Dichlorophenyl)hexyl]tetrahydro-3-hydroxy-2-oxo-3-furanacetic acid

SMILES Code:

O=C(O)C[C@@]1(O)C(O[C@H](CCCCCCC2=CC=C(Cl)C=C2Cl)C1)=O

Code InChi:

InChI=1S/C18H22Cl2O5/c19-13-8-7-12(15(20)9-13)5-3-1-2-4-6-14-10-18(24,1 1-16(21)22)17(23)25-14/h7-9,14,24H,1-6,10-11H2,(H,21,22)/t14-,18-/m1/s1

Ki InChi:

YTRNLFYTHYWDAU-RDTXWAMCSA-N

huaʻōlelo:

SB-204990, SB 204990, SB204990

Hiki ke hoʻoheheʻe: 

Waihona: 

wehewehe:

ʻO SB-204990 ka prodrug o ka potent ATP citrate-lyase inhibitor SB-201076. ʻO SB-204990, i ka wā i hāʻawi ʻia ai i ka waha i nā ʻiole, ua komo i loko o ka ʻōnaehana systemic, ua hoʻihoʻi ʻia nā manaʻo pharmacologically pili o SB-201076 i loko o ke ake. ʻO SB-204990 (25 mg/kg i kēlā lā i kēia lā) ua hoʻemi pū i nā pae cholesterol plasma (a hiki i ka 23%) a me nā pae triglyceride (a hiki i 38%) i ka ʻīlio, ʻoi aku ka maikaʻi e hoʻemi i ka lipoprotein haʻahaʻa haʻahaʻa i hoʻohālikelike ʻia me ka lipoprotein cholesterol kiʻekiʻe. pae. He enzyme koʻikoʻi ka SB-204990 i ka hoʻomalu ʻana i ka lako substrate no ka lipid synthesis de novo a me kahi pahuhopu enzyme kūpono no ka hana hypolipidaemic.

Pahuhopu: